Table 1 Quantitative comparison of three metrics between magnetic particle imaging (MPI) and magnetic resonance imaging (MRI) in specific application scenarios
From: Exploring the diagnostic potential: magnetic particle imaging for brain diseases
Scenarios | Methods | Gradient (T/m) | Sensitivity | Temporal resolution | Spatial resolution | Findings | References |
|---|---|---|---|---|---|---|---|
Detection of MSCs | MPI | 3 | 4000 cells (76 ng Fe) | – | 2 mm | The high sensitivity of MPI facilitates tracking cells and detecting tumor metastasis | [30] |
MRI | 3 | 256,000 cells (9.01 × 1016 19F) | – | 1 mm | |||
CAR T-cell tracking | MPI | 6 | 2000 cells | – | 1 mm | MPI provides a new way for immunization therapy with high sensitivity | [20] |
MRI | 7 | 20,000 cells | – | 200 μm | |||
Ischemic stroke | MPI | 2.5 | – | 21.5 ms | 3 mm | MPI with high temporal resolution is helpful to monitor acute vascular diseases | [60] |
MRI | 7 | – | 177 ms | 130 μm | |||
Brain perfusion | MPI | 2.5 | About 69 MSCs (896 pg Fe) | 21.5 ms | 500 μm | MPI can detect a few tracers with high temporal resolution and has potential for early detection of cerebrovascular diseases | [68] |
MRI | 7 | – | 177 ms | 130 μm | |||
Measurement of CBV | fMPI | 2.83 | CNR = 12–29 | – | 3 mm | fMPI with a low gradient provides much higher CNR than fMRI, promoting its potential to detect weak signals of diseases | [62] |
fMRI | 9.4 | CNR = 5.95 | – | 375 μm (smooth to 3 mm for comparing) |