Fig. 5
From: Exploring the diagnostic potential: magnetic particle imaging for brain diseases
Reproduced with permission from Ref. [26] (a–c). d MPI used SPIONs and an alternating magnetic field (AMF) to achieve magnetic hyperthermia for subcutaneous tumors. The heating site was controlled by moving the field-free line (FFL) to avoid thermal damage to the liver. e The top and bottom tumors in a mouse could be heated separately by moving the FFL. Reproduced with permission from Ref. [65] (d and e)
Magnetic particle imaging (MPI) detection and image-guided magnetothermal therapy for brain tumors. Imaging of orthotopic brain tumor xenografts in mice with multimodality nanoparticles (a–c). In the three-dimension (3D) computerized tomography (CT)/MPI images (a) and two-dimension (2D) axial image (b) of the mouse head, the brain areas showed enhanced MPI contrast after injection compared with that of pre-injection (c).