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Fig. 7 | Military Medical Research

Fig. 7

From: TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients

Fig. 7

Graphical mechanism showing the secretion of TGF-β1 by hOM-MSCs further activates the PI3K-Akt signaling pathway through interaction with microglial cell membrane ALK receptors, thereby regulating the immune response and maintaining autophagy homeostasis. OM-MSCs olfactory mucosa mesenchymal stem cells, LTBP1 latent transforming growth factor beta binding protein 1, TGF-β1 transforming growth factor-β1, ALK anaplastic lymphoma kinase, IRS1 insulin receptor substrate 1, Ras rat sarcoma, PI3K Phosphoinositide 3-kinase, Akt Protein protein kinase B, mTOR mammalian target of rapamycin, IKKs The IκB kinase, IκBs inhibitory κB, NF-κB nuclear factor kappa-B, STAT signal transducer and activator of transcription, TF transcription factor

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Military Medical Research

ISSN: 2054-9369