Biomaterials science and surface engineering strategies for dental peri-implantitis management

Table 4 Summary of the AMP coating

AMPs coating	Fabrication method	Bacteria affected	Antibacterial period	Cell response to the surface	In vivo study	References
GL 13 K	Covalent immobilization via silane-linker	P. gingivalis	5 d	Cytocompatible with HGF and MC3T3-E1	-	[148]
JH8194 and minTBP-1	Immobilization via Pro-rich linker PAPAP	S. gordonii, S. sanguis	6 d	No significant influence on the proliferation of MC3T3-E1	-	[149]
Hlf1-11	Immobilization via silanization or ATRP	S. sanguinis, L. salivarius, oral biofilm	4 weeks	Low cytotoxicity effect on HFFs	-	[150]
TBP-1-RGDS-hBD3-3	Anchoring via TBP-1	S. gordonii, F. nucleatum, P. gingivalis	72 h	No significant influence on the proliferation of MC3T3-E1	-	[46]
TBP-1-GGG-hBD3-3	Anchoring via TBP-1	S. oralis, S. gordonii, S. sanguinis	72 h	No significant cytotoxicity toward MC3T3-E1	-	[46]
Tet213	Layer-by-layer assembly technique	S. aureus, P. gingivalis	1 month	No significant affection on the viability of HaCaT	-	[102]

AMPs antimicrobial peptides, PAPAP pro-rich linker, ATRP atom transfer radical polymerization, TBP-1 Engineered chimeric peptides containing Ti-binding fragments, P. gingivalis Porphyromonas gingivalis, S. gordonii Streptococcus gordonii, S. sanguis Streptococcus sanguis, S. sanguinis Streptococcus sanguinis, L. salivarius Lactobacillus salivarius, S. oralis Streptococcus oralis, S. aureus Staphylococcus aureus, HGF human gingival fibroblasts, MC3T3-E1 mouse embryonic osteoblast precursor cells, HFF human gingival fibroblasts, HaCaT human immortalized keratinocytes

ISSN: 2054-9369